Allergan 100U — OnabotulinumtoxinA | FDA-Approved Original

Allergan 100U — The World's Original 
Botulinum Toxin for Aesthetic Excellence

The benchmark against which all botulinum toxin products are measured. 
Developed by Allergan Aesthetics (an AbbVie company), Botox Cosmetic 
is the original FDA-approved onabotulinumtoxinA — with over 35 years 
of clinical data, the most extensive safety and efficacy record of any 
botulinum toxin product in the world, and the reference standard for 
aesthetic neurotoxin practice globally.

FDA approval history: 1989 (therapeutic) · 2002 (glabellar lines) 
· 2013 (lateral canthal lines) · 2017 (forehead lines) 
· 2023 (platysma bands)

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Product Specifications
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Product Name      : Botox Cosmetic (OnabotulinumtoxinA)
Active Ingredient : OnabotulinumtoxinA
                    (Clostridium botulinum Toxin Type A Complex,
                    Hall Strain)
Concentration     : 100 Allergan Units per vial
Composition       : OnabotulinumtoxinA 100U + Human Serum
                    Albumin (0.5 mg) + Sodium Chloride (0.9 mg)
Appearance        : Sterile vacuum-dried white powder
Preservative      : Preservative-free
Storage (Unopened): 2°C – 8°C refrigeration
Shelf Life        : 36 months (100U vial, unopened)
Storage (Reconst.): 2°C – 8°C, use within 24 hours
Pack Size         : Single-dose vial (100 Units)
Country of Origin : USA / Ireland
Manufacturer      : Allergan Aesthetics (an AbbVie Company)
Certifications    : FDA (USA) · EMA (Europe) · GMP

⚠ Unit Note: Allergan Units are specific to Allergan's proprietary
  assay method. They are NOT interchangeable with units of any other
  botulinum toxin product — Dysport, Nabota, Xeomin, or others.

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Why Botox Cosmetic Remains the Global Standard
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35+ Years of Clinical Data
More peer-reviewed studies, long-term safety data, and clinical 
trials than any other botulinum toxin product in existence. The 
reference point for practitioner training, dosing protocols, 
and comparative research worldwide.

OnabotulinumtoxinA — Allergan's Proprietary Formulation
The neurotoxin complex is purified from Clostridium botulinum 
Hall Strain cultures through a multi-stage precipitation, 
dialysis, and chromatography process — resulting in a 
neurotoxin/hemagglutinin protein complex with approximately 
20 units per nanogram of neurotoxin protein. This specific 
activity profile defines its predictable, precise, and 
localized clinical performance.

Most Widely Trained Toxin Globally
The vast majority of aesthetic practitioners worldwide were 
trained on Botox Cosmetic dosing and injection protocols — 
making it the universal clinical language for neurotoxin practice.

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Clinical Indications (FDA-Approved Aesthetic)
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✔ Glabellar lines (frown lines) — 20 Units standard dose
✔ Lateral canthal lines (crow's feet) — 24 Units per side
✔ Forehead lines — 20 Units standard dose
✔ Platysma bands (neck rejuvenation) — 40–60 Units

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Onset & Duration
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- Initial effect       : 24–72 hours post-injection
- Peak effect          : 1–2 weeks
- Duration             : 3–4 months (aesthetic indications)
- Retreatment interval : No more frequent than every 3 months

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Reconstitution Guide
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100 Unit Vial — Standard Dilutions

Diluent Added    →   Resulting Dose per 0.1 mL
2.5 mL saline    →   4 Units / 0.1 mL  (standard aesthetic)
5.0 mL saline    →   2 Units / 0.1 mL  (skin botox / diffuse)
10.0 mL saline   →   1 Unit  / 0.1 mL  (high-volume therapeutic)

Reconstitute with sterile, preservative-free 0.9% Sodium 
Chloride only. Rotate vial gently — do not shake. 
Administer within 24 hours of reconstitution. 
Single-dose, single-patient use only.

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Botulinum Toxin Comparison — Quick Reference
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                  Botox Cosmetic    Nabota        Dysport
Type              OnaBotA           OnaBotA       AboBotA
Manufacturer      Allergan/AbbVie   Daewoong      Ipsen
Origin            USA / Ireland     Korea         Europe
Unit System       Allergan Units    Daewoong U    Ipsen Units
FDA Approval      1989              2019          2009
Diffusion         Localized         Localized     Wider
Strengths         50U / 100U        100U / 200U   300U / 500U
Shelf Life        36 months         36 months     —
Best For          Universal         Cost-eff.     Larger areas
                  reference std.    Korean-mfg.   & therapeutic

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Safety & Compliance
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✔ FDA-approved since 1989 — longest approval history of any toxin
✔ Preservative-free — single-dose vial
✔ EMA-approved for European markets
✔ GMP-manufactured under Allergan / AbbVie standards
✔ 36-month shelf life (100U unopened, refrigerated)
✔ Cold-chain compliant shipping (2°C – 8°C maintained)

Contraindications: Known hypersensitivity to any botulinum toxin 
preparation or formulation components. Infection at injection site. 
Not for use during pregnancy or lactation.

For use by licensed medical and aesthetic professionals only.
Allergan Units are not interchangeable with any other botulinum 
toxin product. Refer to full prescribing information before use.