Rejuran I — Periorbital PN Booster | Crow's Feet & Dark Circles | 1x1ml

Rejuran I — Periorbital-Specialized PN Skin Booster for the Eye Area

The eye-area variant of Korea's most trusted polynucleotide (PN) skin 
booster line. Rejuran I is engineered by PharmaResearch Co., Ltd. with 
deliberately lower viscosity than Rejuran Healer — making it the only 
Rejuran formulation specifically optimized for safe, precise injection 
into the periorbital zone: crow's feet, under-eye fine lines, and 
dark circles.

Where Rejuran Healer treats the full face, Rejuran I goes where 
standard boosters cannot — delivering targeted PN regeneration to 
the thinnest, most delicate skin on the face without risk of lumping, 
bumping, or Tyndall effect.

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Product Specifications
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Product Name      : Rejuran I (Eye)
Active Ingredient : Polynucleotide (PN) — Salmon DNA-derived
PN Concentration  : 1% (10mg/ml)
Active Substance  : Sodium Polynucleotide
Form              : Low-viscosity injectable solution
Pack Size         : 1 x 1ml pre-filled syringe
Injection Depth   : Superficial dermis (periorbital area)
Needle Size       : 34G (recommended for periorbital)
Storage           : 2°C – 25°C, away from direct light
Shelf Life        : 24 months
Country of Origin : South Korea
Manufacturer      : PharmaResearch Co., Ltd.
Certifications    : KGMP · ISO 13485 · CE · KFDA

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Why Low Viscosity Matters — Rejuran I vs Rejuran Healer
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The skin around the eye is 0.3–0.5mm thick — the thinnest on the 
entire face. Standard PN boosters with higher viscosity carry two 
risks in this zone: visible bumping and uneven distribution.

Rejuran I's low-viscosity formulation addresses this directly:

✔ Seamlessly integrates into thin periorbital skin
✔ No clumping or lump formation risk
✔ Even distribution across superficial dermis
✔ No Tyndall effect — safe for under-eye injection
✔ Faster post-injection recovery vs standard formulas

At 1% PN concentration (vs early-generation 0.2% boosters), 
Rejuran I delivers 5x more regenerative signal per treatment 
volume — maximizing clinical outcome in a zone where dosing 
precision is critical.

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Mechanism of Action — Periorbital Focus
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✔ Collagen & Elastin Synthesis — restores structural proteins 
  depleted in aging periorbital skin, visibly firming the area
✔ Microcirculation Enhancement — improves blood flow beneath 
  the under-eye area, reducing the appearance of dark circles
✔ Dermal Thickening — increases skin density in thinned 
  post-procedure or naturally thin periorbital tissue
✔ Fibroblast Activation — stimulates collagen-producing cells 
  for long-term structural regeneration
✔ Anti-Inflammatory Action — calms periorbital redness, 
  puffiness, and skin sensitivity

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Clinical Indications
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Primary (Periorbital)
✔ Crow's feet (lateral canthal lines)
✔ Fine lines and wrinkles under and around the eyes
✔ Dark circles — improved microcirculation and skin thickness
✔ Under-eye puffiness and hollowness
✔ Thinned periorbital skin post-laser or post-procedure
✔ Loss of elasticity in the eye contour area

Secondary
✔ Perioral fine lines (lip lines, smoker's lines)
✔ Thin-skinned areas of the neck and décolletage

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Treatment Protocol
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- Initial course: 3–4 sessions at 2-week intervals
- Maintenance: every 6–12 months
- Volume per session: 1 syringe (1ml) covers both periorbital zones
- Combination: pair with Rejuran Healer (full face) on same day
- Compatible with: laser treatments, microneedling protocols,
  skin botox for synergistic periorbital rejuvenation

Note: Avoid concurrent use with cross-linked HA fillers.
Do not administer within 12 months of cross-linked HA injection 
due to granuloma risk. Not for use in pregnant or lactating patients.

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Safety & Compliance
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✔ No adverse immune or allergic responses in clinical studies
✔ Minimal downtime — redness/swelling resolves within 24–48 hrs
✔ Safe for sensitive periorbital skin — no Tyndall effect risk
✔ KGMP & ISO 13485 certified manufacturing
✔ CE marked — European medical device compliance

For use by licensed medical and aesthetic professionals only.
Manufactured in South Korea under GMP standards.