Rejuran HB — PN + HA Skin Booster | Hydration & Regeneration | Lidocaine | 1x1ml

Rejuran HB — PN × HA Dual-Action Skin Booster for Regeneration & Hydration

The only Rejuran formulation that combines two regenerative mechanisms 
in a single vial: salmon-derived Polynucleotide (PN) for cellular 
regeneration, and Hyaluronic Acid (HA) for immediate deep hydration — 
with 0.3% Lidocaine for a significantly more comfortable injection 
experience.

Where Rejuran Healer focuses on long-term structural repair, Rejuran HB 
delivers visible results from day one — making it the ideal entry point 
for first-time patients, and the most versatile option for dry, dehydrated, 
or UV-damaged skin that requires both repair and immediate moisture.

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Product Specifications
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Product Name      : Rejuran HB (Hydration Booster)
Active Ingredients: Polynucleotide (PN) 1% + Hyaluronic Acid (HA) 1%
Added Component   : Lidocaine 0.3% (pain reduction)
Form              : Injectable solution
Pack Size         : 1 x 1ml pre-filled syringe
Injection Depth   : Superficial to mid-dermis
Storage           : 2°C – 25°C, away from direct light
Shelf Life        : 24 months
Country of Origin : South Korea
Manufacturer      : PharmaResearch Co., Ltd.
Certifications    : KGMP · ISO 13485 · CE · KFDA

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The PN + HA Synergy — Why the Combination Matters
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PN and HA do not simply coexist in this formula — they amplify 
each other's effects through complementary mechanisms:

PN (Polynucleotide) — Regeneration Layer
Activates fibroblast proliferation, stimulates Type I/III collagen 
and elastin synthesis, and repairs the extracellular matrix (ECM) 
at the cellular level. Long-term structural skin rebuilding.

HA (Hyaluronic Acid) — Hydration Layer
Binds up to 1,000x its weight in water within the dermis, 
delivering immediate volumetric hydration and improving the 
skin's moisture-retention capacity from the first session.

Combined Synergistic Effects
✔ ECM hydration — HA maintains the aqueous environment 
  in which PN-driven fibroblasts function optimally
✔ Accelerated fibroblast proliferation — HA scaffolding 
  enhances PN's cell-signaling efficiency by up to 20%
✔ Collagen synthesis — dual stimulation from both PN 
  (biological) and HA (mechanical) pathways
✔ Skin barrier reinforcement — combined ECM support 
  strengthens the dermal architecture comprehensively

Lidocaine 0.3% — Comfort Protocol
Significantly reduces injection discomfort, making Rejuran HB 
the most patient-friendly option in the Rejuran line — ideal 
for pain-sensitive patients and high-frequency treatment areas.

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Clinical Indications
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Hydration & Glow
✔ Severely dry and dehydrated skin
✔ Dull, fatigued complexion lacking radiance
✔ Moisture-barrier-compromised skin

Regeneration & Anti-Aging
✔ Fine lines and superficial wrinkles
✔ Early-to-moderate signs of skin aging
✔ Loss of skin elasticity and firmness

Damage Repair
✔ UV-damaged and photoaged skin
✔ Skin damaged by excessive cosmetic treatments
✔ Post-laser and post-peel skin recovery

Texture & Tone
✔ Uneven skin tone and roughness
✔ Enlarged pores
✔ Superficial acne scarring

Treatment Areas
✔ Full face and neck
✔ Décolletage
✔ Elbows, knees, and back of hands

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Treatment Protocol
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- Initial course: 3–4 sessions at 3–4 week intervals
- Visible hydration: from Day 1 post-treatment
- Structural improvement: progressive over treatment course
- Duration of effect: 6–12 months
- Maintenance: every 6 months
- Combination: pair with Rejuran Healer for comprehensive
  full-face regeneration + hydration protocol on the same day

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Rejuran HB vs Rejuran Healer — Quick Reference
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                  Rejuran Healer    Rejuran HB
Active            PN only           PN + HA + Lidocaine
Volume            2 x 2ml           1 x 1ml
Hydration         Long-term         Immediate + Long-term
Pain Level        Moderate          Reduced (Lidocaine)
Best For          Regeneration      Regeneration + Hydration
Patient Profile   All skin types    Dry, dehydrated,
                                    first-time patients

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Safety & Compliance
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✔ 2-fold improvement in elasticity vs HA-only boosters (clinical data)
✔ No immune or allergic responses in clinical studies
✔ Lidocaine reduces procedural discomfort significantly
✔ KGMP & ISO 13485 certified manufacturing
✔ CE marked — European medical device compliance
✔ Minimal downtime — redness resolves within 24–48 hrs

Note: Avoid concurrent use with cross-linked HA fillers.
Do not administer within 12 months of cross-linked HA injection 
due to granuloma risk. Not for pregnant or lactating patients.

For use by licensed medical and aesthetic professionals only.
Manufactured in South Korea under GMP standards.