Rejuran Healer — PN Skin Booster | Salmon DNA | 2 x 2ml | PharmaResearch Korea

Rejuran Healer — Korea's Pioneering PN Skin Booster for Cellular Regeneration

The original and most trusted polynucleotide (PN) injectable in Korean 
aesthetic medicine. Developed by PharmaResearch Co., Ltd. using patented 
DOT™ (DNA Optimizing Technology), Rejuran Healer delivers highly purified 
salmon-derived PN directly into the dermis — stimulating the skin's own 
regenerative processes at the cellular level.

Unlike hyaluronic acid boosters that hydrate from the outside in, Rejuran 
Healer rebuilds skin architecture from within — activating fibroblasts, 
restoring collagen and elastin networks, and repairing damaged ECM.

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Product Specifications
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Product Name      : Rejuran Healer (Skin Healer)
Active Ingredient : Polynucleotide (PN) — Salmon DNA-derived
Form              : Injectable solution
Pack Size         : 2 x 2ml pre-filled syringes
Injection Depth   : Superficial to mid-dermis
Needle Size       : 33G x 4mm (recommended)
Storage           : 2°C – 25°C, away from direct light
Shelf Life        : 24 months
Country of Origin : South Korea
Manufacturer      : PharmaResearch Co., Ltd.
Certifications    : KGMP · ISO 13485 · CE · KFDA

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Key Technology — DOT™ (DNA Optimizing Technology)
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Rejuran's proprietary DOT™ technology extracts and purifies PN from 
Korean Chum Salmon (Oncorhynchus keta) — the species with the closest 
DNA base composition to the human genome, ensuring maximum biocompatibility.

PN vs PDRN: What's the Difference?
PDRN (Polydeoxyribonucleotide) is a broader class of DNA fragments.
PN (Polynucleotide) is a more purified, concentrated form with longer 
chain structures — enabling extended presence in dermal tissue, stronger 
regenerative activity, and more consistent clinical outcomes.

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Mechanism of Action
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✔ Fibroblast Activation — stimulates proliferation of skin's collagen-
  producing cells by up to 20%, driving long-term structural repair
✔ Collagen & Elastin Synthesis — promotes Type I/III collagen growth 
  and elastin network restoration for improved skin density and firmness
✔ Anti-Inflammatory Action — scavenges free radicals and blocks 
  inflammatory cytokines, reducing redness and skin sensitivity
✔ ECM Restoration — rebuilds the extracellular matrix framework 
  that deteriorates with age and UV exposure
✔ Growth Factor Stimulation — enhances microcirculation and accelerates 
  natural wound healing processes in the dermis

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Clinical Indications
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Skin Regeneration & Anti-Aging
✔ Fine lines and wrinkles (periorbital, perioral, forehead, neck)
✔ Skin laxity and loss of elasticity
✔ Skin thinning and reduced dermal density

Texture & Tone
✔ Enlarged pores
✔ Uneven skin tone and dullness
✔ Sebum-moisture imbalance

Scar & Damage Repair
✔ Atrophic acne scars
✔ Post-laser and post-procedure skin recovery
✔ Sun damage and photoaging repair
✔ Stretch marks

Rejuran Line Variants
✔ Rejuran Healer   — Full face, all skin types (standard PN)
✔ Rejuran I        — Periocular area, crow's feet, under-eye (fine PN)
✔ Rejuran S        — Depressed and sunken acne scars (viscous PN)
✔ Rejuran HB       — PN + HA combination for enhanced hydration

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Treatment Protocol
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- Initial course: 3–4 sessions at 2–4 week intervals
- Visible improvement: from 2–3 days post-treatment
- Optimal results: after completion of full session course
- Maintenance: once every 6–9 months
- Injection volume: approximately 2ml per full face treatment
- Compatible with: mesotherapy, microneedling, skin botox protocols

Note: Avoid concurrent use with cross-linked HA fillers. 
Do not use in patients who have received cross-linked HA injections 
within the prior 12 months due to granuloma risk.

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Safety & Compliance
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✔ Highly biocompatible — salmon DNA closely mirrors human genome structure
✔ No immune or allergic response reported in clinical studies
✔ KGMP & ISO 13485 certified manufacturing
✔ CE marked — compliant with European medical device regulations
✔ Minimal downtime — 2–5 day recovery; redness resolves within 24–48 hrs

For use by licensed medical and aesthetic professionals only.
Manufactured in South Korea under GMP standards.